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Pulmonary aspiration—where food material, saliva, or some other substance accidentally enters a person’s airway and may end up in the lungs—has a less-defined relationship with GLP-1 drugs. Though there’s no confirmed causation between GLP-1 drugs and the three side effects named by the FDA, previous research has made connections between them. Glucagon-like peptide-1 (GLP-1) receptor agonist drugs have been linked to side effect case reports on the FDA’s Adverse Event Reporting System (FAERS). Now, the drugs are included in an FDA review list, updated last on January 2. Put the used WEGOVY pen in an FDA-cleared sharps disposal container right away after use.
Some people taking weight loss drugs say they're experiencing hair loss
With other GLP-1 receptor agonists and other semaglutide products, some cases of acute pancreatitis have been fatal. According to the manufacturer, acute pancreatitis was reported in studies in 5 patients taking Wegovy vs. 1 patient on placebo (an inactive shot). “What is really striking for folks is that there are no scalp symptoms.
How does it work for weight loss?
Inform patients of the risk of hypoglycemia and educate patients on the signs and symptoms of hypoglycemia. Advise patients with diabetes mellitus on glycemic lowering therapy that they may have an increased risk of hypoglycemia when using WEGOVY and to report signs and/or symptoms of hypoglycemia to their healthcare provider [see WARNINGS AND PRECAUTIONS]. In patients with diabetes, monitor blood glucose prior to starting WEGOVY and during WEGOVY treatment.
Can you prevent hair loss when losing weight?
This is especially true for people who have already taken the medication and are seeing good results. The investigation was initially supposed to wrap in November, but the EMA’s committee recently sent “further lists of questions to be addressed” to companies marketing GLP-1 drugs. Currently, the FDA is simply “evaluating the need for regulatory action”—drug companies are not yet being asked to do anything, such as updating warnings on their package labels. If blood appears at the injection site, press the site lightly with a gauze pad or cotton ball.
“Patients who stopped taking Wegovy at the end of the clinical trial regained most of their weight within a year. The decision to both start Wegovy and stop Wegovy should be done carefully in the care of a clinician who understands obesity” said Patel. Though the FDA review is important, there’s no need for people to be “stressing out over it,” especially when, for now, there’s no proven link between GLP-1 drugs and alopecia, aspiration, or suicidal ideation, said Rafi. This review comes about six months after the European Medicines Agency (EMA) announced that they’d be reviewing a possible link between GLP-1 drugs and suicidal ideation after receiving about 150 case reports of the issue. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
Can Ozempic, Wegovy Cause Hair Loss and Suicidal Ideation? FDA Investigating GLP-1 Drug Side Effects
Adverse reactions reported in clinical trials in adults and greater than or equal to 2% of WEGOVY-treated patients and more frequently than in placebo-treated patients are shown in Table 3. As with other protein and peptide pharmaceuticals, patients receiving this drug have developed anti-semaglutide antibodies. The detection of antibody formation is highly dependent on the sensitivity and specificity of the assay, as well as other factor in handling of the sample. For these reasons, the incidence of antibodies cannot be directly compared with other products. Anti-drug antibodies to semaglutide have been reported in up to 1% of patients during clinical trials. In a 2-year trial among patients with type 2 diabetes and high cardiovascular risk, patients treated with this drug experienced a great incidence of diabetic retinopathy complications (3% vs 1.8%).
Dr. Priya Jaisinghani, an endocrinologist at NYU Langone in New York City, said that poor diet, calorie restriction or protein restriction can contribute to hair loss that’s seen with significant weight loss. Hair loss is a common side effect of significant weight loss during a short period of time, and people who undergo bariatric, or weight loss surgery, are usually warned ahead of time that this could be a side effect. Low blood sugar (hypoglycemia) is also a common side effect when used in people taking certain other diabetes treatments like sulfonylureas or insulin) and can be serious. The glucagon-like peptide-1 (GLP-1) receptor agonists are well-known for causing stomach side effects, but these are typically tolerable and short-term for most people. These include mild or moderate nausea, diarrhea, vomiting, constipation, belching, heartburn, reflux and stomach pain. Jaisinghani also advises people not to assume hair loss is because of weight loss.
Possible Ozempic side effects, including hair loss, probed by FDA; no link found to suicidal thoughts - CBS News
Possible Ozempic side effects, including hair loss, probed by FDA; no link found to suicidal thoughts.
Posted: Thu, 11 Jan 2024 08:00:00 GMT [source]
Guidance issued last March by the National Institute for Health and Care Excellence (NICE) states that the time constraint comes from a lack of evidence for long-term use and limited access to specialized weight-management services. Some people who have lowered their weight with the medication can maintain their new physique through diet and exercise alone, says Sharma. However, these individuals are at high risk of weight rebound if they return to old habits or undergo a stressful situation, he adds. Only 18 reports of patients taking semaglutide or tirzepatide in FDA's database mention aspiration, which refers to when people inhale food or other objects into their airway. Doctors have also noted the higher number of patients who reported alopecia in Eli Lilly's trials of tirzepatide for obesity.
Wegovy side effects
The drugs work by targeting receptors in the body that are involved with producing insulin and regulating digestion. Usually, once your weight stabilizes, this side effect will subside and your hair will regrow to its original thickness before you started treatment. Although you may notice hair thinning, other people may not recognize it all. A provider can go over your medical history and perform any necessary testing to rule out other potential conditions. In the meantime, prices are extremely high for out-of-pocket purchases. Employers can't wait for price discounts and drugmakers have little incentive to offer price concessions as demand soars.
If your doctor confirms you’ve had a serious allergic reaction to Wegovy, they may have you switch to a different treatment. Talk with your doctor if you have concerns about possible long-term side effects from using Wegovy. If you have questions about how long Wegovy side effects may take to go away, talk with your doctor. If you develop serious side effects while using Wegovy, call your doctor right away. Wegovy may cause mild side effects other than the ones listed above. Your thyroid is a small gland found in the front of your neck area.
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. If you will be using semaglutide at home, your doctor will teach you how the injections will be given. Be sure you understand exactly how the medicine is to be injected.
Price is now paying more than $1,300 out of pocket per month to continue on Wegovy. It's more than she can afford, which means she's looking at discontinuing the life-changing medication altogether. Research has shown what happens when people stop taking GLP-1 agonists.
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